328634

1-Methyl-2-pyrrolidinone

anhydrous, 99.5%

• Synonym(s): 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP
• Empirical Formula (Hill Notation): C₅H₉NO
• CAS Number: 872-50-4
• Molecular Weight: 99.13
• Beilstein: 106420
• EC Number: 212-828-1
• MDL number: MFCD00003193
• UNSPSC Code: 12352005
• PubChem Substance ID: 57648684
• NACRES: NA.21

Properties

• grade: anhydrous
• Quality Level: 200
• vapor density: 3.4 (vs air)
• vapor pressure: 0.29 mmHg ( 20 °C); 0.99 mmHg ( 40 °C)
• Assay: 99.5%
• form: liquid
• autoignition temp.: 518 °F
• expl. lim.: 9.5 %
• impurities: <0.005% water
• refractive index: n20/D 1.47 (lit.)
• pH: 7.7-10.0 (20 °C, 100 g/L)
• bp: 202 °C (lit.); 81-82 °C/10 mmHg (lit.)
• mp: −24 °C (lit.)
• density: 1.028 g/mL at 25 °C (lit.)
• SMILES string: CN1CCCC1=O
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• InChI key: SECXISVLQFMRJM-UHFFFAOYSA-N

Description

Application

1-Methyl-2-pyrrolidinone may be used as a solvent in the following processes:

• Preparation of 2-aryl and 2-alkyl benzothiazoles.
• Ullmann coupling reaction of aryl halides and phenols to form Ullmann ethers in the presence of 2,2,6,6-tetramethylheptane-3,5-dione.
• Stille cross-coupling reaction of aryl iodides with organostannanes catalyzed by Pd/C in the presence of copper iodide as cocatalyst.

Packaging

View returnable container options.

Other Notes

Pure-Pac^® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H315 - H319 - H335 - H360D
• Precautionary Statements: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point(F): 195.8 °F - Pensky-Martens closed cup
• Flash Point(C): 91 °C - Pensky-Martens closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves