RFX5
regulatory factor X, 5 (influences HLA class II expression)
Synonyms:
Species:
Human RFX5 (5993), Mouse Rfx5 (53970), Rat Rfx5 (310659), cow RFX5 (539884), sheep RFX5 (101115494), Domestic Rabbit RFX5 (100328902), naked mole-rat Rfx5 (101698005), domestic guinea pig Rfx5 (100719654), Horse RFX5 (100055472), domestic cat RFX5 (101099317)
UniProtKB ID:
Gene ID:
- Human(5993) Summary: A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]
- Mouse(53970) regulatory factor X, 5 (influences HLA class II expression)
- Rat(310659) regulatory factor X, 5 (influences HLA class II expression)
- cow(539884) regulatory factor X, 5 (influences HLA class II expression)
- sheep(101115494) regulatory factor X, 5 (influences HLA class II expression)
- Domestic Rabbit(100328902) regulatory factor X, 5 (influences HLA class II expression)
- naked mole-rat(101698005) regulatory factor X, 5 (influences HLA class II expression)
- domestic guinea pig(100719654) regulatory factor X, 5 (influences HLA class II expression)
- Horse(100055472) regulatory factor X, 5 (influences HLA class II expression)
- domestic cat(101099317) regulatory factor X, 5 (influences HLA class II expression)
- dog(483197) regulatory factor X, 5 (influences HLA class II expression)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-RFX5 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-RFX5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-RFX5 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, mouse, pig, rat
Application
ELISA
western blot
western blot
Anti-Rfx5 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-RFX5 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot