MBD2
methyl-CpG binding domain protein 2
Synonyms:
DMTase, NY-CO-41
Species:
Human MBD2 (8932), Mouse Mbd2 (17191), Rat Mbd2 (680172), Zebrafish mbd2 (337105), chicken MBD2 (497269), cow MBD2 (100337206), domestic cat MBD2 (101096114), dog MBD2 (483975), naked mole-rat Mbd2 (101707030), domestic guinea pig Mbd2 (100735208)
UniProtKB ID:
Gene ID:
- Human(8932) Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Mouse(17191) methyl-CpG binding domain protein 2
- Rat(680172) methyl-CpG binding domain protein 2
- Zebrafish(337105) methyl-CpG binding domain protein 2
- chicken(497269) methyl-CpG binding domain protein 2
- cow(100337206) methyl-CpG binding domain protein 2
- domestic cat(101096114) methyl-CpG binding domain protein 2
- dog(483975) methyl-CpG binding domain protein 2
- naked mole-rat(101707030) methyl-CpG binding domain protein 2
- domestic guinea pig(100735208) methyl-CpG binding domain protein 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MBD2 Antibody, clone 4D4D5, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
western blot
Anti-MBD2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-MBD2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-MBD2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-MBD2a,b (RA-18) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunofluorescence
microarray
western blot
microarray
western blot
esiRNA
Product Number
Description
Species