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Merck

ELANE

elastase, neutrophil expressed

Synonyms:
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
Species:
Human ELANE (1991), Mouse Elane (50701), Rat Elane (299606), sheep ELANE (101110841), domestic guinea pig Elane (100724414), cow ELANE (100126050), Horse ELANE (100462967), domestic cat ELANE (100301482), dog ELANE (442980)
UniProtKB ID:
P08246, P09649, Q6B0D9, Q6LDP5
Gene ID:
  • Human(1991) Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
  • Mouse(50701) elastase, neutrophil expressed
  • Rat(299606) elastase, neutrophil expressed
  • sheep(101110841) elastase, neutrophil expressed
  • domestic guinea pig(100724414) elastase, neutrophil expressed
  • cow(100126050) elastase, neutrophil expressed
  • Horse(100462967) elastase, neutrophil expressed
  • domestic cat(100301482) elastase, neutrophil expressed
  • dog(442980) elastase, neutrophil expressed

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB5703017
Anti-Neutrophil Elastase (ELANE) Antibody, clone 8X4E6, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
HPA073774
Anti-Elane Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
HPA066836
Anti-ELANE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
SAB1305716
ANTI-NEUTROPHIL ELASTASE(N-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB5500151
Anti-Neutrophil Elastase antibody, Rabbit monoclonal, clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry

Proteins

Product Number
Description
Species
E8140
Elastase from human leukocytes, lyophilized powder, ≥50 units/mg protein (Bradford),
Species
human
A6150
α1-Antitrypsin from human plasma, salt-free, lyophilized powder,
Species
human

esiRNA

Product Number
Description
Species
EHU003711
MISSION® esiRNA, targeting human ELANE,
Species
human