Fatal fulminant hepatic failure due to cyproterone acetate.

Fatal fulminant hepatic failure due to cyproterone acetate.

Digestive diseases and sciences (1999-09-18)

G Friedman, E Lamoureux, A H Sherker

ABSTRACT

Cyproterone acetate is a normally well-tolerated drug that is used widely for the treatment of prostatic carcinoma. Liver toxicity due to its use is not well known. We describe two cases of fatal fulminant hepatitis related to the use of cyproterone acetate.

MATERIALS

Product Number

Brand

Product Description

C3412

Sigma-Aldrich

Cyproterone acetate, ≥98%

C3283000

Cyproterone acetate, European Pharmacopoeia (EP) Reference Standard

Y0001390

Cyproterone acetate for peak identification, European Pharmacopoeia (EP) Reference Standard