- Ligand-directed tosyl chemistry for protein labeling in vivo.
Ligand-directed tosyl chemistry for protein labeling in vivo.
Nature chemical biology (2009-03-31)
Shinya Tsukiji, Masayoshi Miyagawa, Yousuke Takaoka, Tomonori Tamura, Itaru Hamachi
PMID19330012
ABSTRACT
Here we describe a method for the site-selective attachment of synthetic molecules into specific 'endogenous' proteins in vivo using ligand-directed tosyl (LDT) chemistry. This approach was applied not only for chemically labeling proteins in living cells, tissues and mice but also for constructing a biosensor directly inside cells without genetic engineering. These data establish LDT chemistry as a new tool for the study and manipulation of biological systems.
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