SMB01381
SAICAriboside
≥95% (HPLC), from synthetic, solid
Synonym(s):
N-Succinyl-5-aminoimidazole-4-carboxamide Ribose
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About This Item
Empirical Formula (Hill Notation):
C13H18N4O9
CAS Number:
Molecular Weight:
374.30
MDL number:
UNSPSC Code:
12352211
UNSPSC Code:
12352200
NACRES:
NA.26
Recommended Products
biological source
synthetic
Quality Level
Assay
≥95% (HPLC)
form
solid
color
white to beige
mp
130-135 °C
storage temp.
2-8°C
SMILES string
NC1=C(C(N[C@H](C(O)=O)CC(O)=O)=O)N=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2
General description
SAICAR (a ribotide) can lose its phosphate group leading to the appearance of a riboside known as succinylaminoimidazolecarboxamide riboside (SAICAriboside or SAICAr) in cerebrospinal fluid, in urine, and, to a lesser extent, in plasma. SAICAriboside is characteristic of ADSL, a heritable deficiency of the enzyme adenylosuccinate lyase (ASL or adenylosuccinase) responsible for metabolizing SAICAR (SZMP) to AICAR (ZMP) and adenylosuccinate (SAMP) to AMP. ASL deficiency causes increased SAICAR & SAMP, and their corresponding rephosphorylated products SAICAr & succinyladenosine (S-Ado).
Storage and Stability
Heat sensitive
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Roxane Marsac et al.
Genetics, 211(4), 1297-1313 (2019-02-01)
Purine homeostasis is ensured through a metabolic network widely conserved from prokaryotes to humans. Purines can either be synthesized de novo, reused, or produced by interconversion of extant metabolites using the so-called recycling pathway. Although thoroughly characterized in microorganisms, such
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