CH2900018
Calcium Levofolinate Hydrate / Levoleucovorin Calcium Pentahydrate
Ph. Eur.
Pharma Manufacturing
Synonym(s):
L-Calcium Folinate, L-Leucovorin Calcium, Levofolinate Calcium Hydrate, Levoleucovorin Calcium
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About This Item
UNSPSC Code:
41116107
Recommended Products
biological source
synthetic
Quality Level
grade
GMO free
GMP
Halal
Kosher
Agency
Ph. Eur.
USP
form
powder
application(s)
liquid formulation
pharmaceutical
solid formulation
storage temp.
2-8°C
General description
We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Application
Calcium Levofolinate Hydrate has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.
Packaging
Customized packaging possible
Legal Information
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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