573127

STAT3 Inhibitor XII, SPI

The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): STAT3 Inhibitor XII, SPI
• Empirical Formula (Hill Notation): C₁₄₆H₂₃₈N₄₀O₄₂
• Molecular Weight: 3225.69
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 100 mg/mL; DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.

The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Tyr-Lys-Pro-Pro-Gly-Tyr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Zhao, W., et al. 2010. J. Biol. Chem.285, 35855.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable