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Sigma-Aldrich

L-Methionine-13C5,15N

98 atom % 13C, 98 atom % 15N, 95% (CP)

Synonym(s):

SILAC Amino Acid, L-Methionine-ul-13C,15N

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About This Item

Linear Formula:
13CH3S13CH213CH213CH(15NH2)13CO2H
CAS Number:
202468-47-1
Molecular Weight:
155.17
MDL number:
MFCD00209757
UNSPSC Code:
12352209
PubChem Substance ID:
329759230
NACRES:
NA.12

isotopic purity

98 atom % 13C
98 atom % 15N

Assay

95% (CP)

form

solid

optical activity

[α]25/D +23.1°, c = 1 in 1 M HCl

technique(s)

bio NMR: suitable
protein expression: suitable

mp

284 °C (dec.) (lit.)

mass shift

M+6

SMILES string

[13CH3]S[13CH2][13CH2][13C@H]([15NH2])[13C](O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1

InChI key

FFEARJCKVFRZRR-XAFSXMPTSA-N

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Application

L-Methionine-13C5,15N can be used as an internal standard in the analysis of amino acids in human plasma and serum using various analytical techniques.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

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Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Aaron Issaian et al.
Haematologica (2021-05-14)
Band 3 (anion exchanger 1 - AE1) is the most abundant membrane protein in red blood cells (RBCs), the most abundant cell in the human body. A compelling model posits that - at high oxygen saturation - the N-term cytosolic
Comparison of orthogonal liquid and gas chromatography--mass spectrometry platforms for the determination of amino acid concentrations in human plasma
McGaw EA, et al.
Journal of Chromatography A, 1217(37), 5822-5831 (2010)
High-speed quantitative UPLC-MS analysis of multiple amines in human plasma and serum via precolumn derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate: application to acetaminophen-induced liver failure
Gray N, et al.
Analytical Chemistry, 89(4), 2478-2487 (2017)
Dominic G Roy et al.
Cell metabolism, 31(2), 250-266 (2020-02-06)
Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics, we showed that methionine is

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