TNNI1
troponin I type 1 (skeletal, slow)
Synonyms:
SSTNI, TNN1
Species:
Human TNNI1 (7135), Mouse Tnni1 (21952), Rat Tnni1 (29388), cow TNNI1 (100301375), Goat TNNI1 (100860774), domestic guinea pig Tnni1 (100733717), naked mole-rat Tnni1 (101720739), chicken TNNI1 (421161), domestic cat TNNI1 (101096197), dog TNNI1 (100685160)
UniProtKB ID:
Gene ID:
- Human(7135) Summary: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
- Mouse(21952) troponin I, skeletal, slow 1
- Rat(29388) troponin I type 1 (skeletal, slow)
- cow(100301375) troponin I type 1 (skeletal, slow)
- Goat(100860774) troponin I type 1 (skeletal, slow)
- domestic guinea pig(100733717) troponin I type 1 (skeletal, slow)
- naked mole-rat(101720739) troponin I type 1 (skeletal, slow)
- chicken(421161) troponin I type 1 (skeletal, slow)
- domestic cat(101096197) troponin I type 1 (skeletal, slow)
- dog(100685160) troponin I type 1 (skeletal, slow)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TNNI1 (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-TNNI1 (AB2) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-Cardiac Troponin I Antibody, clone 1F23, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-Troponin I1/TnI1 Antibody, clone 5K1U2, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Proteins
Product Number
Description
Species
Troponin1, His tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human