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Merck

NEFL

neurofilament, light polypeptide

Synonyms:
CMT1F, CMT2E, NF-L, NF68, NFL
Species:
UniProtKB ID:
Gene ID:
  • Human(4747) Summary: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
  • Mouse(18039) neurofilament, light polypeptide
  • Rat(83613) neurofilament, light polypeptide
  • chicken(419528) neurofilament, light polypeptide
  • cow(281348) neurofilament, light polypeptide
  • domestic cat(101081039) neurofilament, light polypeptide
  • dog(477378) neurofilament, light polypeptide
  • naked mole-rat(101704332) neurofilament, light polypeptide
  • domestic guinea pig(100731797) neurofilament, light polypeptide
  • sheep(101119539) neurofilament, light polypeptide

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-NEFL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Neurofilament 70 kDa Antibody, clone DA2, culture supernatant, clone DA2, Chemicon®,
Species Reactivity
bovine, human, mouse, pig, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-phospho-NFL (Ser473) Antibody, clone 4F8, clone 4F8, from mouse,
Species Reactivity
bovine, human, mouse, porcine, rat, rhesus macaque
Application
immunohistochemistry
western blot
Neurofilament (EP79) Rabbit Monoclonal Primary Antibody, ,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-NEFL antibody produced in mouse, clone 2G10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot

Proteins

Product Number
Description
Species
Neurofilament 70 kDa, porcine, ,
Species

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NEFL,
Species
human