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Merck

GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Synonyms:
GluN1, MRD8, NMDA1, NMDAR1, NR1
Species:
UniProtKB ID:
Gene ID:
  • Human(2902) Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  • Mouse(14810) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • Rat(24408) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • chicken(404296) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • dog(494007) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • Horse(100059861) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • cow(100336579) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • domestic guinea pig(100301989) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • naked mole-rat(101720185) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • sheep(443281) glutamate receptor, ionotropic, N-methyl D-aspartate 1

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Small Molecule - Agonist

Product Number
Description
Species
D-Serine, ≥98% (TLC),
Species
human
Spermine tetrahydrochloride, powder or crystals,
Species
human
Taurine, ≥99%,
Species
human, rat
D-Cycloserine, synthetic,
Species
human
N-Methyl-D-aspartic acid, ≥98% (TLC), solid,
Species
human, rat

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Acamprosate calcium, British Pharmacopoeia (BP) Reference Standard,
Species
human
Acamprosate calcium, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
Species
human
Acamprosate calcium, ≥98% (HPLC), powder,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
MDL 105,519, ≥98% (HPLC), solid,
Species
rat, human
CP-101,606, ≥98% (HPLC),
Species
human
Ifenprodil (+)-tartrate salt, ,
Species
human
Arcaine sulfate salt, ,
Species
human
(±)-CPP, solid,
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GRIN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-NMDAR1 Splice Variant C1 Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
western blot
Anti-NMDAR1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Monoclonal Anti-Glun1-Nr1 antibody produced in mouse, clone S308-48, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-Glun1-Nr1 - Fitc antibody produced in mouse, clone S308-48, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot

Small Molecule - Blocker

Product Number
Description
Species
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Species
human
Agmatine sulfate salt, ≥97%, powder,
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Taurine, ≥99%,
Species
human, rat
Pentamidine isethionate salt, powder,
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Grin1,
Species
mouse
MISSION® esiRNA, targeting human GRIN1,
Species
human