- Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Cancer research (2017-08-05)
Yun-Chi Tang, Hui Yuwen, Kaiying Wang, Peter M Bruno, Kevin Bullock, Amy Deik, Stefano Santaguida, Marianna Trakala, Sarah J Pfau, Na Zhong, Tao Huang, Lan Wang, Clary B Clish, Michael T Hemann, Angelika Amon
PMID28775166
ABSTRACT
Aneuploidy, a hallmark of cancer cells, poses an appealing opportunity for cancer treatment and prevention strategies. Using a cell-based screen to identify small molecules that could selectively kill aneuploid cells, we identified the compound
MATERIALS