- Thioredoxin induces Tregs to generate an immunotolerant tumor microenvironment in metastatic melanoma.
Thioredoxin induces Tregs to generate an immunotolerant tumor microenvironment in metastatic melanoma.
Oncoimmunology (2015-09-26)
Xiaogang Wang, Haisheng Dong, Qi Li, Yingxian Li, An Hong
PMID26405597
ABSTRACT
Metastatic melanoma is a highly aggressive cancer that is very difficult to treat. Additionally, the antitumor immune reaction of melanoma is still unclear. Here we demonstrate an association between the expression and secretion of the antioxidant protein thioredoxin (TRX) and increasing tumor stage and metastasis in melanoma. To elucidate the role of TRX in melanoma, we assessed the correlation of TRX expression with different disease parameters in melanoma. We also examined the
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Hydrogen peroxide solution, semiconductor grade VLSI PURANAL™ (Honeywell 17606), ≥30%
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Ethyl alcohol, Pure, 190 proof, ACS reagent, meets USP testing specifications, Excise Tax-free, Permit for use required
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