- 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).
Bioorganic & medicinal chemistry letters (2001-08-22)
D A Heerding, G Chan, W E DeWolf, A P Fosberry, C A Janson, D D Jaworski, E McManus, W H Miller, T D Moore, D J Payne, X Qiu, S F Rittenhouse, C Slater-Radosti, W Smith, D T Takata, K S Vaidya, C C Yuan, W F Huffman
PMID11514139
ABSTRACT
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.