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Isoflavonoids with antiestrogenic activity from Millettia pachycarpa.

Journal of natural products (2006-01-31)
Chihiro Ito, Masataka Itoigawa, Minako Kumagaya, Yoshinori Okamoto, Koji Ueda, Tsutomu Nishihara, Nakao Kojima, Hiroshi Furukawa
ABSTRACT

Three new isoflavonoids, named millewanins G (1) and H (2) and furowanin B (3), were isolated from the leaves of Millettia pachycarpa. Their structures were elucidated on the basis of spectroscopic analyses. The antiestrogenic activity in the yeast two-hybrid assay of these isoflavonoids was examined and shown to be comparable with that of 4-hydroxytamoxifen.