Skip to Content
Merck

PTEN

phosphatase and tensin homolog

Synonyms:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Species:
UniProtKB ID:
Gene ID:
  • Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
  • Mouse(19211) phosphatase and tensin homolog
  • Rat(50557) phosphatase and tensin homolog
  • fruit fly(43991) CG5671 gene product from transcript CG5671-RB
  • domestic cat(101091813) phosphatase and tensin homolog
  • dog(403832) phosphatase and tensin homolog
  • chicken(423675) phosphatase and tensin homolog
  • cow(540786) phosphatase and tensin homolog
  • sheep(101119351) phosphatase and tensin homolog
  • domestic guinea pig(100723659) phosphatase and tensin homolog
  • naked mole-rat(101714930) phosphatase and tensin homolog

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PTEN Antibody, clone 6H2.1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-Cleaved PTEN antibody, Rabbit monoclonal, clone SP227, recombinant, expressed in proprietary host, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
Monoclonal Anti-PTEN (phospho S380/T382/T383) antibody produced in rabbit, clone E4,
Species Reactivity
human
Application
flow cytometry
Anti-PTEN antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
Anti-Phospho-PTEN-S370 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, ,
Species
mouse
MISSION® esiRNA, targeting human PTEN,
Species
human