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Merck

NDUFV1

NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa

Synonyms:
CI-51K, CI51KD, UQOR1
Species:
UniProtKB ID:
Gene ID:
  • Human(4723) Summary: The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
  • Mouse(17995) NADH dehydrogenase (ubiquinone) flavoprotein 1
  • Rat(293655) NADH dehydrogenase (ubiquinone) flavoprotein 1
  • Zebrafish(445291) NADH dehydrogenase (ubiquinone) flavoprotein 1
  • chicken(430210) NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
  • dog(476004) NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
  • cow(287014) NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
  • domestic cat(101093395) NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
  • sheep(101121129) NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
  • naked mole-rat(101726275) NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
  • domestic guinea pig(100725831) NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-NDUFV1 antibody produced in mouse, clone 4A7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-NDUFV1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-NDUFV1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
1,1-Dimethylbiguanide hydrochloride, 97%,
Species
human
Metformin hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Metformin hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Metformin hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Metformin hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ndufv1,
Species
mouse
MISSION® esiRNA, targeting human NDUFV1,
Species
human