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Merck

NDUFS4

NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)

Synonyms:
AQDQ, CI-18
Species:
UniProtKB ID:
Gene ID:
  • Human(4724) Summary: This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008]
  • Mouse(17993) NADH dehydrogenase (ubiquinone) Fe-S protein 4
  • Rat(499529) NADH dehydrogenase (ubiquinone) Fe-S protein 4
  • naked mole-rat(101699557) NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
  • sheep(101118899) NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
  • Zebrafish(573689) NADH dehydrogenase (ubiquinone) Fe-S protein 4, (NADH-coenzyme Q reductase)
  • cow(327680) NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
  • domestic cat(101089240) NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
  • dog(479335) NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
  • chicken(374122) NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-NDUFS4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-NDUFS4 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Monoclonal Anti-NDUFS4, (C-terminal) antibody produced in mouse, clone 1A1, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
Monoclonal Anti-NDUFS4 antibody produced in mouse, clone 1A1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Monoclonal Anti-NDUFS4 antibody produced in mouse, clone 3A4, ascites fluid, solution,
Species Reactivity
human
Application
ELISA

Small Molecule - Inhibitor

Product Number
Description
Species
1,1-Dimethylbiguanide hydrochloride, 97%,
Species
human
Metformin hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Metformin hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Metformin hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Metformin hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NDUFS4,
Species
human
MISSION® esiRNA, targeting mouse Ndufs4,
Species
mouse