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Merck

GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Synonyms:
GluN1, MRD8, NMDA1, NMDAR1, NR1
Species:
UniProtKB ID:
Gene ID:
  • Human(2902) Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  • Mouse(14810) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • Rat(24408) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • chicken(404296) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • dog(494007) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • Horse(100059861) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • cow(100336579) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • domestic guinea pig(100301989) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • naked mole-rat(101720185) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • sheep(443281) glutamate receptor, ionotropic, N-methyl D-aspartate 1

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
Spermine tetrahydrochloride, powder or crystals,
Species
human
D-Serine, ≥98% (TLC),
Species
human
Taurine, ≥99%,
Species
human, rat
D-Cycloserine, synthetic,
Species
human
Dextromethorphan hydrobromide monohydrate, ≥99% (TLC),
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
S-(+)-Ketamine hydrochloride, ,
Species
human
Ketamine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
(±)-Ketamine hydrochloride, solid,
Species
human
Acamprosate calcium, ≥98% (HPLC), powder,
Species
human
Acamprosate calcium, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
CP-101,606, ≥98% (HPLC),
Species
human
MDL 105,519, ≥98% (HPLC), solid,
Species
rat, human
Arcaine sulfate salt, ,
Species
human
Dextrorphan tartrate, powder,
Species
human
(±)-2-Amino-4-phosphonobutyric acid, solid,
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Phospho-GRIN1-S890 antibody produced in rabbit, ,
Species Reactivity
human, rat
Application
western blot
Anti-GRIN1 (Ab-897) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
Anti-phospho-GRIN1 (pSer896) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Monoclonal Anti-Glun1-Nr1 - Percp antibody produced in mouse, clone S308-48, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-Glun1-Nr1 - Rpe antibody produced in mouse, clone S308-48, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot

Small Molecule - Blocker

Product Number
Description
Species
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Species
human
Agmatine sulfate salt, ≥97%, powder,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Taurine, ≥99%,
Species
human, rat
Pentamidine isethionate salt, powder,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Grin1,
Species
mouse
MISSION® esiRNA, targeting human GRIN1,
Species
human