F9
coagulation factor IX
Synonyms:
FIX, HEMB, P19, PTC, THPH8
Species:
Human F9 (2158), Mouse F9 (14071), Rat F9 (24946), chicken F9 (374258), dog F9 (404015), domestic cat F9 (493973), cow F9 (280688), Horse F9 (100054449), domestic guinea pig F9 (100135464), naked mole-rat F9 (101724977) ...More
UniProtKB ID:
Gene ID:
- Human(2158) Summary: This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008]
- Mouse(14071) coagulation factor IX
- Rat(24946) coagulation factor IX
- chicken(374258) coagulation factor IX
- dog(404015) coagulation factor IX
- domestic cat(493973) coagulation factor IX
- cow(280688) coagulation factor IX
- Horse(100054449) coagulation factor IX
- domestic guinea pig(100135464) coagulation factor IX
- naked mole-rat(101724977) coagulation factor IX
- sheep(443316) coagulation factor IX
- Domestic Rabbit(100009113) coagulation factor IX
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