AXIN1
axin 1
Synonyms:
AXIN, PPP1R49
Species:
Human AXIN1 (8312), Mouse Axin1 (12005), Rat Axin1 (79257), Zebrafish axin1 (57931), cow AXIN1 (504357), Horse AXIN1 (100065116), domestic cat AXIN1 (101088804), dog AXIN1 (490099), chicken AXIN1 (395786), sheep AXIN1 (101122656) ...More
UniProtKB ID:
Gene ID:
- Human(8312) Summary: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
- Mouse(12005) axin 1
- Rat(79257) axin 1
- Zebrafish(57931) axin 1
- cow(504357) axin 1
- Horse(100065116) axin 1
- domestic cat(101088804) axin 1
- dog(490099) axin 1
- chicken(395786) axin 1
- sheep(101122656) axin 1
- domestic guinea pig(100718536) axin 1
- naked mole-rat(101700795) axin 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-AXIN1 antibody produced in mouse, clone 2B11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
proximity ligation assay
western blot
immunofluorescence
proximity ligation assay
western blot
Anti-Axin1 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot