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Merck

Failure to Inactivate Nuclear GSK3β by Ser

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2017-08-24)
Tina M Thornton, Brendan Hare, Sandra Colié, William W Pendlebury, Angel R Nebreda, William Falls, Diane M Jaworski, Mercedes Rincon
PMID28832021
RESUMEN

GSK3β plays an essential role in promoting cell death and is emerging as a potential target for neurological diseases. Understanding the mechanisms that control neuronal GSK3β is critical. A ubiquitous mechanism to repress GSK3β involves Akt-mediated phosphorylation of Ser