- T-cell-targeted signaling inhibitors.
T-cell-targeted signaling inhibitors.
International reviews of immunology (2008-02-27)
Jonghwa Won, Ge Hyeong Lee
PMID18300054
RESUMEN
Recent advances in our understanding of the mechanisms of T-cell activation, migration to inflammatory sites, and pathologic disease processes triggered the development of a wide variety of T-cell-targeted signaling inhibitors, which have different targets and modes of action. Depending on the distribution and the role of targets in disease processes, T-cell inhibitors exhibit different levels of efficacy and potential side effects. This review outlines target molecules to which T-cell inhibitors have been developed, their efficacy, and potential safety concerns of T-cell inhibitors.
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