- Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone.
Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone.
The Journal of organic chemistry (2011-01-05)
Atul K Hajare, Velayutham Ravikumar, Shaik Khaleel, Debnath Bhuniya, D Srinivasa Reddy
PMID21192736
RESUMEN
An efficient synthesis of potent molluscicidal agent cyanolide A, a glycosidic 16-membered macrolide, starting from D-(-)-pantolactone is reported. Highly stereoselective aldol, oxa-Michael addition, and Yamaguchi macrolactonization are the key steps in the present synthesis.