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Merck

Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

Bioorganic & medicinal chemistry letters (1999-01-05)
L D Gegnas, S T Waddell, R M Chabin, S Reddy, K K Wong
RESUMEN

A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.

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5-Phospho-D-ribose 1-diphosphate pentasodium salt, ≥75% (HPLC)
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