- Optimization of the reduction of 74As(V) to 74As(III) and of the labelling of dithiol dihydrolipoic acid.
Optimization of the reduction of 74As(V) to 74As(III) and of the labelling of dithiol dihydrolipoic acid.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2019-04-29)
Zita Oláh, Andreas T J Vogg, Tibor Kremmer, Zoltán Szűcs, Zoltán Varga, Rita Dóczi
PMID31029937
RESUMEN
The radiochemical separation of n.c.a. arsenic on its own or for radio-labelling purposes usually involves the issue of reducing arsenic(V). Numerous approaches for reducing pentavalent arsenic have been examined. A novel HPLC method has also been presented for accessing the efficiency of the reduction in terms of *As(III)/*As(V). Labelling with trivalent radioarsenic seems to be a promising research field to access new radiopharmaceuticals, for example, using arsenic as a surrogate for phosphorus. Moreover, as a model system, the labelling reaction of *As(III) with dihydrolipoic acid has been systematically optimized.