H4001

Hydrocortisone

≥98% (HPLC)

• Sinónimos: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
• Fórmula empírica (notación de Hill): C₂₁H₃₀O₅
• Número de CAS: 50-23-7
• Peso molecular: 362.46
• Beilstein/REAXYS Number: 1354819
• EC Number: 200-020-1
• MDL number: MFCD00011654
• UNSPSC Code: 51111800
• PubChem Substance ID: 24278466
• NACRES: NA.77

Propiedades

• biological source: synthetic (organic)
• Quality Level: 300
• sterility: non-sterile
• assay: ≥98% (HPLC)
• form: powder
• mp: 211-214 °C (lit.)
• solubility: water: 0.28 g/L at 25 °C
• application(s): cell analysis
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866) ; mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) ; rat ... Ar(24208) , Nr3c1(24413)

Descripción

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H360Df,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges