C7374

CK-636

≥98% (HPLC)

• Sinónimos: CK-0944636; N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
• Fórmula empírica (notación de Hill): C₁₆H₁₆N₂OS
• Número de CAS: 442632-72-6
• Peso molecular: 284.38
• MDL number: MFCD03036245
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: peach to light pink
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1[nH]c2ccccc2c1CCNC(=O)c3cccs3
• InChI: 1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
• InChI key: ACAKNPKRLPMONU-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable