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Merck
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38790

Sigma-Aldrich

(±)-Pinostrobin

≥99.0% (TLC)

Sinónimos:

(RS)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one

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About This Item

Fórmula empírica (notación de Hill):
C16H14O4
Número de CAS:
75291-74-6
Peso molecular:
270.28
MDL number:
MFCD00017481
UNSPSC Code:
12352106
PubChem Substance ID:
329755783
NACRES:
NA.25

assay

≥99.0% (TLC)

SMILES string

COc1cc(O)c2C(=O)CC(Oc2c1)c3ccccc3

InChI

1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3

InChI key

ORJDDOBAOGKRJV-UHFFFAOYSA-N

Application

(±)-Pinostrobin, a chiral flavonoid (±), may be used in the development of analytical methods for separation of its individual enantiomers. Pinostrobin may be used to study its neuroprotective antioxidant effects.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Alka Jaudan et al.
PloS one, 13(2), e0191523-e0191523 (2018-02-09)
Pinostrobin (PN) is a naturally occurring dietary bioflavonoid, found in various medicinal herbs/plants. Though anti-cancer potential of many such similar constituents has been demonstrated, critical biochemical targets and exact mechanism for their apoptosis-inducing actions have not been fully elucidated. The
Yan-Fang Xian et al.
Cellular and molecular neurobiology, 32(8), 1223-1230 (2012-05-09)
Beta-Amyloid peptide (Aβ), a major protein component of brain senile plaques in Alzheimer's disease (AD), has been considered as a critical cause in the pathogenesis of AD. Pinostrobin, a potent flavonoid inducer, is the major and most active ingredient of
Monika Asztemborska et al.
Electrophoresis, 24(15), 2527-2531 (2003-08-06)
Micellar electrokinetic chromatography (MEKC) was applied for enantioseparation of selected flavanones, including naringin, hesperidin, neohesperidin, naringenin, hesperetin, pinostrobin, isosakuranetin, eriodictyol, and homoeriodictyol. gamma-Cyclodextrin (gamma-CD) and sodium cholate (SCh) were used as chiral modifiers inducing enantioselectivity to the background electrolyte. From
Stereospecific analytical method development and preliminary in vivo pharmacokinetic characterization of pinostrobin in the rat.
Sayre CL, Zhang Y, Martinez SE, et al.
Biomedical Chromatography (2012)
Karen J Marsh et al.
Phytochemistry, 160, 31-39 (2019-01-27)
A group of plant specialised metabolites (PSMs) collectively known as unsubstituted B-ring flavanones (UBFs) have previously been found in the foliage of some species from the genus Eucalyptus L'Hér. (Myrtaceae), specifically from the subgenus Eucalyptus (monocalypts). Captive feeding studies using
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