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E1800000

Ethacrynic acid

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

(2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid

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About This Item

Fórmula empírica (notación de Hill):
C13H12Cl2O4
Número de CAS:
58-54-8
Peso molecular:
303.14
MDL number:
MFCD00056693
UNSPSC Code:
41116107
PubChem Substance ID:
329799018
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

ethacrynic acid

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O

InChI

1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChI key

AVOLMBLBETYQHX-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethacrynic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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[Action and mode of action of a new original diuretic: ethacrynic acid].
M Salvador et al.
Journal de medecine de Bordeaux et du Sud-Ouest, 143(8), 1105-1118 (1966-08-01)
Toxicity of ethacrynic acid and furosemide.
L B Cooperman et al.
American heart journal, 85(6), 831-834 (1973-06-01)
J H Ploemen et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(8), 913-923 (1993-08-01)
1. The diuretic drug ethacrynic acid (EA) is a potent reversible inhibitor of rat and human glutathione S-transferases (GST), with I50-values (microM) of 4.6-6.0, 0.3-1.9 and 3.3-4.8 for alpha, mu and pi-class, respectively. 2. The reversible inhibition by the glutathione
Ototoxicity of ethacrynic acid (a persistent clinical problem).
L P Rybak
The Journal of laryngology and otology, 102(6), 518-520 (1988-06-01)
[Action and mode of action of a new original diuretic: ethacrynic acid].
M Salvador et al.
Actualites cardiologiques et angeiologiques internationales, 15(2), 101-107 (1966-01-01)
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