444241
MMP-2/MMP-9 Inhibitor I
The MMP-2/MMP-9 Inhibitor I, also referenced under CAS 193807-58-8, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Sinónimos:
MMP-2/MMP-9 Inhibitor I, (2R)-2-[(4-Biphenylylsulfonyl)amino]-3-phenylpropionic Acid
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About This Item
Fórmula empírica (notación de Hill):
C21H19NO4S
Número de CAS:
Peso molecular:
381.44
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent inhibitor of MMP-2 (IC50 = 310 nM) and MMP-9 (IC50 = 240 nM). Orally active in animal models of tumor growth and metastasis.
A potent inhibitor of MMP-2 (gelatinase A; IC50 = 310 nM) and MMP-9 (gelatinase B; IC50 = 240 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-2, MMP-9
MMP-2, MMP-9
Product does not compete with ATP.
Reversible: no
Target IC50: 310 nM and 240 nM against MMP-2 and MMP-9
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Tamura, Y., et al. 1998. J. Med. Chem.41, 640.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Y Tamura et al.
Journal of medicinal chemistry, 41(4), 640-649 (1998-03-04)
Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro and in vivo activities to inhibit type IV collagenase (MMP-9 and MMP-2). When the amino acid residue and the sulfonamide moiety were modified, their inhibitory activities were greatly
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