236011

COX-2 Inhibitor I

The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Sinónimos: COX-2 Inhibitor I, LM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
• Fórmula empírica (notación de Hill): C₁₈H₁₆ClNO₄S
• Número de CAS: 416901-58-1
• Peso molecular: 377.84
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: methanol: 1 mg/mL; DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC₅₀ = 650 nM) and in whole blood (IC₅₀ = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC₅₀ >10 µM) and in whole blood (IC₅₀ >100 µM).

A cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC₅₀ = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC₅₀ = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
COX-2 from human monocytes

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Palomer, A., et al. 2002. J. Med. Chem.45, 1402.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable