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Merck

VHL

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Sinónimos:
HRCA1, RCA1, VHL1, pVHL
Especie:
Human VHL (7428), Mouse Vhl (22346), Rat Vhl (24874), fruit fly Vhl (53433), domestic cat VHL (101092590), dog VHL (494000), chicken VHL (416117), Zebrafish vhl (791202), cow VHL (540957), sheep VHL (101122897)
ID UniProtKB:
P40337, B2RE45, Q13599, Q6PDA9
ID del gen:
  • Human(7428) Summary: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(22346) von Hippel-Lindau tumor suppressor
  • Rat(24874) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • fruit fly(53433) von Hippel-Lindau
  • domestic cat(101092590) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • dog(494000) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • chicken(416117) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • Zebrafish(791202) von Hippel-Lindau tumor suppressor
  • cow(540957) von Hippel-Lindau tumor suppressor
  • sheep(101122897) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • domestic guinea pig(100729230) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA068954
Anti-Vhl Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
SAB4503075
Anti-VHL antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry
ZRB2230
Anti-VHL Antibody, clone 1C10 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, rat
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot

Proteins

Referencia del producto
Descripción
Especie
SRP2084
VHL human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU074571
MISSION® esiRNA, targeting human VHL,
Especie
human
EMU012571
MISSION® esiRNA, targeting mouse Vhl,
Especie
mouse