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Merck

SMC1A

structural maintenance of chromosomes 1A

Sinónimos:
CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Especie:
ID UniProtKB:
ID del gen:
  • Human(8243) Summary: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008]
  • Mouse(24061) structural maintenance of chromosomes 1A
  • Rat(63996) structural maintenance of chromosomes 1A
  • Zebrafish(559665) structural maintenance of chromosomes 1A
  • chicken(395187) structural maintenance of chromosomes 1A
  • dog(480928) structural maintenance of chromosomes 1A
  • domestic cat(101090170) structural maintenance of chromosomes 1A
  • cow(282370) structural maintenance of chromosomes 1A
  • sheep(101120550) structural maintenance of chromosomes 1A
  • domestic guinea pig(100723138) structural maintenance of chromosomes 1A
  • naked mole-rat(101713253) structural maintenance of chromosomes 1A

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Antibodies

Product Number
Descripción
Reactividad de especies
Aplicación
Anti-SMC1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
Anti-Phospho-SMC1-S957 antibody produced in rabbit, ,
Reactividad de especies
human, mouse
Aplicación
western blot
Rabbit anti-Phospho SMC1 (S957) Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Reactividad de especies
human
Aplicación
immunoprecipitation (IP)
western blot
Anti-phospho-SMC1A (pSer957) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
Anti-Phospho-SMC1A-S957 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot

esiRNA

Product Number
Descripción
Especie
MISSION® esiRNA, targeting human SMC1A,
Especie
human
MISSION® esiRNA, targeting mouse Smc1a,
Especie
mouse