SHC1
SHC (Src homology 2 domain containing) transforming protein 1
Sinónimos:
SHC, SHCA
Especie:
Human SHC1 (6464), Mouse Shc1 (20416), Rat Shc1 (85385), Zebrafish shc1 (323818), dog SHC1 (490439), Horse SHC1 (100063053), domestic cat SHC1 (101092911), chicken SHC1 (395934), cow SHC1 (507196), sheep SHC1 (101113548) ...Más
ID UniProtKB:
ID del gen:
- Human(6464) Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Mouse(20416) src homology 2 domain-containing transforming protein C1
- Rat(85385) SHC (Src homology 2 domain containing) transforming protein 1
- Zebrafish(323818) SHC (Src homology 2 domain containing) transforming protein 1
- dog(490439) SHC (Src homology 2 domain containing) transforming protein 1
- Horse(100063053) SHC (Src homology 2 domain containing) transforming protein 1
- domestic cat(101092911) SHC (Src homology 2 domain containing) transforming protein 1
- chicken(395934) SHC (Src homology 2 domain containing) transforming protein 1
- cow(507196) SHC (Src homology 2 domain containing) transforming protein 1
- sheep(101113548) SHC (Src homology 2 domain containing) transforming protein 1
- naked mole-rat(101717434) SHC (Src homology 2 domain containing) transforming protein 1
- domestic guinea pig(100734561) SHC (Src homology 2 domain containing) transforming protein 1
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-SHC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-phospho-SHC1 (pTyr349) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
western blot
western blot
Anti-Phospho-SHC1-Y427 antibody produced in rabbit, ,
Reactividad de especies
human, mouse
Aplicación
western blot
Anti-SHC antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-SHC antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot