ROCK1
Rho-associated, coiled-coil containing protein kinase 1
Sinónimos:
P160ROCK, ROCK-I
Especie:
Human ROCK1 (6093), Mouse Rock1 (19877), Rat Rock1 (81762), Zebrafish rock1 (100329779), dog ROCK1 (480181), Horse ROCK1 (100034056), chicken ROCK1 (373970), domestic guinea pig Rock1 (100718968), naked mole-rat Rock1 (101710589), Domestic Rabbit ROCK1 (100009220) ...Más
ID UniProtKB:
ID del gen:
- Human(6093) Summary: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]
- Mouse(19877) Rho-associated coiled-coil containing protein kinase 1
- Rat(81762) Rho-associated coiled-coil containing protein kinase 1
- Zebrafish(100329779) Rho-associated, coiled-coil containing protein kinase 1
- dog(480181) Rho-associated, coiled-coil containing protein kinase 1
- Horse(100034056) Rho-associated, coiled-coil containing protein kinase 1
- chicken(373970) Rho-associated, coiled-coil containing protein kinase 1
- domestic guinea pig(100718968) Rho-associated, coiled-coil containing protein kinase 1
- naked mole-rat(101710589) Rho-associated, coiled-coil containing protein kinase 1
- Domestic Rabbit(100009220) Rho-associated, coiled-coil containing protein kinase 1
- cow(785911) Rho-associated, coiled-coil containing protein kinase 1
- sheep(100294662) Rho-associated, coiled-coil containing protein kinase 1
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Antibodies
Product Number
Descripción
Reactividad de especies
Aplicación
Anti-ROCK-1 Antibody, clone 3K23 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-ROCK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-ROCK1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-ROCK1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-ROCK-1 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
immunoprecipitation (IP)
microarray
western blot
microarray
western blot
Small Molecule - Inhibitor
Product Number
Descripción
Especie
Proteins
Product Number
Descripción
Especie
ROCK1 (17-535), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
esiRNA
Product Number
Descripción
Especie