PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
Sinónimos:
AMPK, AMPK2, AMPKa2, PRKAA
Especie:
Human PRKAA2 (5563), Mouse Prkaa2 (108079), Rat Prkaa2 (78975), cow PRKAA2 (538954), sheep PRKAA2 (100127210), domestic guinea pig Prkaa2 (100713170), naked mole-rat Prkaa2 (101698482), Zebrafish prkaa2 (572074), Horse PRKAA2 (100034159), domestic cat PRKAA2 (101096000) ...Más
ID UniProtKB:
ID del gen:
- Human(5563) Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
- Mouse(108079) protein kinase, AMP-activated, alpha 2 catalytic subunit
- Rat(78975) protein kinase, AMP-activated, alpha 2 catalytic subunit
- cow(538954) protein kinase, AMP-activated, alpha 2 catalytic subunit
- sheep(100127210) protein kinase, AMP-activated, alpha 2 catalytic subunit
- domestic guinea pig(100713170) protein kinase, AMP-activated, alpha 2 catalytic subunit
- naked mole-rat(101698482) protein kinase, AMP-activated, alpha 2 catalytic subunit
- Zebrafish(572074) protein kinase, AMP-activated, alpha 2 catalytic subunit
- Horse(100034159) protein kinase, AMP-activated, alpha 2 catalytic subunit
- domestic cat(101096000) protein kinase, AMP-activated, alpha 2 catalytic subunit
- chicken(429110) protein kinase, AMP-activated, alpha 2 catalytic subunit
- dog(489571) protein kinase, AMP-activated, alpha 2 catalytic subunit
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-phos-AMPKα (Thr172) Antibody, clone 5J23 , ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
Anti-PRKAA2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti- AMPKα2 antibody produced in rabbit, ,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-Phospho-AMPKa1/AMPKa2-T183/T172 antibody produced in rabbit, ,
Reactividad de especies
human, mouse
Aplicación
western blot
Proteins
Referencia del producto
Descripción
Especie
AMPK (α2/β2/γ2), active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
AMPK (α2/β2/γ1), active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
esiRNA
Referencia del producto
Descripción
Especie