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Merck

POLR2A

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Sinónimos:
POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
Especie:
ID UniProtKB:
ID del gen:
  • Human(5430) Summary: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
  • Mouse(20020) polymerase (RNA) II (DNA directed) polypeptide A
  • Rat(363633) polymerase (RNA) II (DNA directed) polypeptide A
  • domestic guinea pig(100734232) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • naked mole-rat(101725588) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • cow(282312) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • sheep(100144762) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • Zebrafish(553347) polymerase (RNA) II (DNA directed) polypeptide A
  • dog(479483) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • domestic cat(101098500) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-phospho-RNA polymerase II CTD (pSer2) antibody produced in rat, clone 3E7C7, purified from hybridoma cell culture,
Reactividad de especies
Aplicación
flow cytometry
immunofluorescence

western blot
Anti-POLR2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-RNA polymerase II Antibody, clone CTD4H8 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat, yeast
Aplicación
flow cytometry
immunocytochemistry

immunohistochemistry

western blot
Goat anti-RNA Polymerase II Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Reactividad de especies
human, mouse
Aplicación
immunoprecipitation (IP)
western blot
Anti-POLR2A Antibody, clone 3G21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunohistochemistry

western blot

Proteins

Referencia del producto
Descripción
Especie
RNA Polymerase II, C-terminal domain, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Especie
human
RNA Polymerase II, C-terminal human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human POLR2A,
Especie
human
MISSION® esiRNA, targeting mouse Polr2a,
Especie
mouse