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Merck

PDE4B

phosphodiesterase 4B, cAMP-specific

Sinónimos:
DPDE4, PDE4B5, PDEIVB
Especie:
Human PDE4B (5142), Mouse Pde4b (18578), Rat Pde4b (24626), Domestic Rabbit PDE4B (100355058), naked mole-rat Pde4b (101703441), domestic guinea pig Pde4b (100720296), cow PDE4B (100124505), sheep PDE4B (101111757), chicken PDE4B (424700), Horse PDE4B (100053961) ...Más
ID UniProtKB:
Q07343, O15443, Q13945, Q5TEK4, Q5TEK5, Q5TEK6
ID del gen:
  • Human(5142) Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Mouse(18578) phosphodiesterase 4B, cAMP specific
  • Rat(24626) phosphodiesterase 4B, cAMP specific
  • Domestic Rabbit(100355058) phosphodiesterase 4B, cAMP-specific
  • naked mole-rat(101703441) phosphodiesterase 4B, cAMP-specific
  • domestic guinea pig(100720296) phosphodiesterase 4B, cAMP-specific
  • cow(100124505) phosphodiesterase 4B, cAMP-specific
  • sheep(101111757) phosphodiesterase 4B, cAMP-specific
  • chicken(424700) phosphodiesterase 4B, cAMP-specific
  • Horse(100053961) phosphodiesterase 4B, cAMP-specific
  • domestic cat(101081316) phosphodiesterase 4B, cAMP-specific
  • dog(479540) phosphodiesterase 4B, cAMP-specific

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Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
P1784
Pentoxifylline, solid,
Especie
human, rat
W222402
Caffeine, anhydrous, 99%, FCC, FG,
Especie
mouse, human, rat
B8279
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, solid,
Especie
human, rat
C1778
Caffeine, Sigma Reference Standard, vial of 250 mg,
Especie
mouse, human, rat
27602
Caffeine, anhydrous, tested according to Ph. Eur.,
Especie
mouse, human, rat

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA003005
Anti-PDE4B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
ZRB1583
Anti-PDE4B Antibody, clone 1E9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
P3510
Papaverine hydrochloride, powder,
Especie
human
SML1099
Roflumilast, ≥98% (HPLC),
Especie
human
Z0878
Zaprinast, solid,
Especie
human
SML0517
Amlexanox, ≥98% (HPLC),
Especie
human
I0157
Ibudilast, ≥99% (HPLC), solid,
Especie
human

Proteins

Referencia del producto
Descripción
Especie
SRP0263
PDE4B1 Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Especie
rat
SRP0264
PDE4B2 Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Especie
rat

esiRNA

Referencia del producto
Descripción
Especie
EMU070101
MISSION® esiRNA, targeting mouse Pde4b,
Especie
mouse
EHU134591
MISSION® esiRNA, targeting human PDE4B,
Especie
human