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Merck

LDLR

low density lipoprotein receptor

Sinónimos:
FH, FHC, LDLCQ2
Especie:
Human LDLR (3949), Mouse Ldlr (16835), Rat Ldlr (300438), Zebrafish ldlr (387529), dog LDLR (100683160), chicken LDLR (395103), domestic cat LDLR (101080362), cow LDLR (281276), Domestic Rabbit LDLR (100009086), domestic guinea pig Ldlr (100724238)
ID UniProtKB:
P01130, B4DII3, B4DJZ8, B4DR00, B4DTQ3, C0JYY8, H0YLU8, H0YNT7
ID del gen:
  • Human(3949) Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
  • Mouse(16835) low density lipoprotein receptor
  • Rat(300438) low density lipoprotein receptor
  • Zebrafish(387529) low density lipoprotein receptor
  • dog(100683160) low density lipoprotein receptor
  • chicken(395103) low density lipoprotein receptor
  • domestic cat(101080362) low density lipoprotein receptor
  • cow(281276) low density lipoprotein receptor
  • Domestic Rabbit(100009086) low density lipoprotein receptor
  • domestic guinea pig(100724238) low density lipoprotein receptor
  • naked mole-rat(101703463) low density lipoprotein receptor

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ELISA

Referencia del producto
Descripción
Especie
RAB0707
Human LDLR / Low-density Lipoprotein Receptor ELISA Kit, ,
Especie
human
RAB1810
Rhesus Macaque LDL Reptor ELISA, for serum, plasma and cell culture supernatants,
Especie

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
ZRB1176
Anti-LDL Receptor Antibody, clone 2N19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, rat
Aplicación
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
HPA009647
Anti-LDLR antibody produced in rabbit, Ab1, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
SAB5702280
Anti-LDL Receptor (LDLR) Antibody, clone 10K4L8, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
immunofluorescence
western blot
GW22458A
Anti-LDLR antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
SAB3500286
Anti-LDL-R antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
western blot

Proteins

Referencia del producto
Descripción
Especie
SRP6477
LDLR human, recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE),
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EMU015661
MISSION® esiRNA, targeting mouse Ldlr,
Especie
mouse
EHU152551
MISSION® esiRNA, targeting human LDLR,
Especie
human