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Merck

HSD11B2

hydroxysteroid (11-beta) dehydrogenase 2

Sinónimos:
AME, AME1, HSD11K, HSD2, SDR9C3
Especie:
ID UniProtKB:
ID del gen:
  • Human(3291) Summary: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
  • Mouse(15484) hydroxysteroid 11-beta dehydrogenase 2
  • Rat(25117) hydroxysteroid 11-beta dehydrogenase 2
  • Zebrafish(334098) hydroxysteroid 11-beta dehydrogenase 2
  • cow(282434) hydroxysteroid (11-beta) dehydrogenase 2
  • Horse(100034124) hydroxysteroid (11-beta) dehydrogenase 2
  • domestic cat(100529249) hydroxysteroid (11-beta) dehydrogenase 2
  • dog(489758) hydroxysteroid (11-beta) dehydrogenase 2
  • chicken(100857283) hydroxysteroid (11-beta) dehydrogenase 2
  • Domestic Rabbit(100009531) hydroxysteroid (11-beta) dehydrogenase 2
  • domestic guinea pig(100733422) hydroxysteroid (11-beta) dehydrogenase 2
  • naked mole-rat(101712460) hydroxysteroid (11-beta) dehydrogenase 2

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-HSD11B2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
Anti-HSD11B2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
18β-Glycyrrhetinic acid, 97%,
Especie
rat, human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human HSD11B2,
Especie
human