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HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

Sinónimos:
LDLCQ3
Especie:
ID UniProtKB:
ID del gen:
  • Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Mouse(15357) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
  • Rat(25675) 3-hydroxy-3-methylglutaryl-CoA reductase
  • fruit fly(42803) HMG Coenzyme A reductase
  • chicken(395145) 3-hydroxy-3-methylglutaryl-CoA reductase
  • cow(407159) 3-hydroxy-3-methylglutaryl-CoA reductase
  • Horse(100065577) 3-hydroxy-3-methylglutaryl-CoA reductase
  • domestic cat(101098922) 3-hydroxy-3-methylglutaryl-CoA reductase
  • dog(479182) 3-hydroxy-3-methylglutaryl-CoA reductase
  • domestic guinea pig(100726509) 3-hydroxy-3-methylglutaryl-CoA reductase
  • naked mole-rat(101717005) 3-hydroxy-3-methylglutaryl-CoA reductase
  • sheep(101108919) 3-hydroxy-3-methylglutaryl-CoA reductase

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Activity Assay

Product Number
Descripción
Especie
HMG-CoA Reductase Assay Kit, sufficient for 30 assays (1 mL), sufficient for 100 assays (200 μL),
Especie
human

Antibodies

Product Number
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-HMGCR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0259, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
Anti-HMGCR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-HMGCR (internal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
Anti-HMGCR antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
Monoclonal Anti-HMGCR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0260, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Descripción
Especie
(+)-γ-Tocopherol, ≥96% (HPLC),
Especie
human
(+)-γ-Tocopherol, analytical standard,
Especie
human
Simvastatin, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Pravastatin sodium salt hydrate, ≥98% (HPLC), powder,
Especie
human
Simvastatin, United States Pharmacopeia (USP) Reference Standard,
Especie
human

Proteins

Product Number
Descripción
Especie
3-Hydroxy-3-methylglutaryl-CoA reductase human, solution,
Especie
human

esiRNA

Product Number
Descripción
Especie
MISSION® esiRNA, targeting mouse Hmgcr,
Especie
mouse
MISSION® esiRNA, targeting human HMGCR,
Especie
human