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Merck

HLA-B

major histocompatibility complex, class I, B

Sinónimos:
AS, HLAB, SPDA1
Especie:
Human HLA-B (3106)
ID UniProtKB:
P30464, B0V0B8, P30465, P30513, Q29633, Q29636, Q29829, Q29953
ID del gen:
  • Human(3106) Summary: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
ZRB2779
Anti-HLA-B Antibody, clone 1L21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
affinity binding assay
flow cytometry
immunofluorescence
immunohistochemistry
western blot
H1650
Monoclonal Anti-HLA Class I Antigen antibody produced in mouse, clone W6/32, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human, monkey
Aplicación
flow cytometry
immunofluorescence
immunoprecipitation (IP)
F5662
Monoclonal Anti-HLA Class I Antigen−FITC antibody produced in mouse, clone W6/32, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human, monkey
Aplicación
flow cytometry
immunofluorescence
SAB5703013
Anti-MHC class I (HLA-A/B) Antibody, clone 3I1C1, Rabbit Monoclonal, ,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot