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Merck

GRIN2B

glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Sinónimos:
GluN2B, MRD6, NMDAR2B, NR2B, hNR3
Especie:
ID UniProtKB:
ID del gen:
  • Human(2904) Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
  • Mouse(14812) glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • Rat(24410) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • chicken(417965) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • dog(494009) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic cat(101094356) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • Horse(100063746) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • cow(537804) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic guinea pig(100731840) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • naked mole-rat(101723091) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • sheep(101118179) glutamate receptor, ionotropic, N-methyl D-aspartate 2B

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
Reversin 205, ≥98% (HPLC), film,
Especie
mouse, rat, human
D-Cycloserine, synthetic,
Especie
human
Dextromethorphan hydrobromide monohydrate, ≥99% (TLC),
Especie
human
N-Methyl-D-aspartic acid, ≥98% (TLC), solid,
Especie
human, rat
(S)-AMPA, ≥97%,
Especie
mouse, human, rat

Small Molecule - Allosteric Modulator

Referencia del producto
Descripción
Especie
Acamprosate calcium, ≥98% (HPLC), powder,
Especie
human
Acamprosate calcium, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
Especie
human
Acamprosate calcium, British Pharmacopoeia (BP) Reference Standard,
Especie
human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
DL-2-Aminoadipic acid, ≥99%,
Especie
rat
2-Phenylquinoline, 99%,
Especie
rat
Ro 25-6981 hydrochloride hydrate, ≥98% (HPLC), powder,
Especie
human
Ro 8-4304, solid,
Especie
human
Spermine, ≥97%,
Especie
rat, human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
PhosphoDetect Anti-NMDA NR2B (pTyr¹⁴⁷²) Rabbit pAb, liquid, Calbiochem®,
Reactividad de especies
rat
Aplicación
Anti-NMDAR2B Antibody, clone 5C18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
bovine, canine, feline, monkey, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-GRIN2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-NMDAR2B antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
Anti-Phospho-GRIN2B-Y1070 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
western blot

Small Molecule - Blocker

Referencia del producto
Descripción
Especie
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Especie
human
Agmatine sulfate salt, ≥97%, powder,
Especie
human

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Pentamidine isethionate salt, powder,
Especie
human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Especie
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Especie
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Especie
rat, human
L-Glutamic acid, FCC,
Especie
rat, human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human GRIN2B,
Especie
human
MISSION® esiRNA, targeting mouse Grin2b,
Especie
mouse