ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Sinónimos:
ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Especie:
Human ERBB3 (2065), Mouse Erbb3 (13867), Rat Erbb3 (29496), sheep ERBB3 (101103889), Domestic Rabbit ERBB3 (100008807), naked mole-rat Erbb3 (101721671), domestic guinea pig Erbb3 (100712946), chicken ERBB3 (693245), cow ERBB3 (785655), Horse ERBB3 (100059216) ...Más
ID UniProtKB:
ID del gen:
- Human(2065) Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
- Mouse(13867) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- Rat(29496) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- sheep(101103889) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- Domestic Rabbit(100008807) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- naked mole-rat(101721671) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- domestic guinea pig(100712946) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- chicken(693245) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
- cow(785655) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- Horse(100059216) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- domestic cat(101085388) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- dog(481105) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
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ELISA
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-ERBB3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-ERBB3 (Ab-1328) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-HER3 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
western blot
Anti-Erbb3 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
Anti-C-ERBB3 antibody, Rabbit monoclonal, clone SP71, recombinant, expressed in proprietary host, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
Proteins
Referencia del producto
Descripción
Especie