DUSP6
dual specificity phosphatase 6
Sinónimos:
HH19, MKP3, PYST1
Especie:
Human DUSP6 (1848), Mouse Dusp6 (67603), Rat Dusp6 (116663), Zebrafish dusp6 (353314), cow DUSP6 (515310), Horse DUSP6 (100051565), domestic cat DUSP6 (101097255), dog DUSP6 (482594), chicken DUSP6 (374272), naked mole-rat Dusp6 (101697963) ...Más
ID UniProtKB:
ID del gen:
- Human(1848) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(67603) dual specificity phosphatase 6
- Rat(116663) dual specificity phosphatase 6
- Zebrafish(353314) dual specificity phosphatase 6
- cow(515310) dual specificity phosphatase 6
- Horse(100051565) dual specificity phosphatase 6
- domestic cat(101097255) dual specificity phosphatase 6
- dog(482594) dual specificity phosphatase 6
- chicken(374272) dual specificity phosphatase 6
- naked mole-rat(101697963) dual specificity phosphatase 6
- domestic guinea pig(100720904) dual specificity phosphatase 6
- sheep(101110315) dual specificity phosphatase 6
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-DUSP6 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-DUSP6 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Anti-DUSP6 Antibody, clone 1H14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
canine, human, monkey, porcine, rat
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-DUSP6 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
western blot