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Merck

CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

Sinónimos:
CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1
Especie:
Human CYP2D6 (1565), chicken CYP2D6 (417981), domestic cat CYP2D6 (100500743), sheep CYP2D6 (100568286)
ID UniProtKB:
P10635, Q16752, Q2XND6, Q2XND7, Q2XNE0, Q6B012, Q6NXU8
ID del gen:
  • Human(1565) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • chicken(417981) cytochrome P450, family 2, subfamily D, polypeptide 6
  • domestic cat(100500743) cytochrome 2D6
  • sheep(100568286) cytochrome P450 2D6

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA045223
Anti-CYP2D6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
SAB4500595
Anti-Cytochrome P450 2D6 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
ELISA
western blot
SAB5702749
Anti-CYP2D6 Antibody, clone 1X3F0, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
immunofluorescence
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
241571
Quinoline, reagent grade, 98%,
Especie
human
C80407
Cinchonidine, 96%,
Especie
human
C0253
Chlorambucil, ,
Especie
human
183067
6-Methoxyquinoline, 98%,
Especie
human
27370
Cinchonine, crystallized, ≥98.0% (NT),
Especie
human

Proteins

Referencia del producto
Descripción
Especie
MTOXCE2D6
CypExpress™ 2D6 Cytochrome P450 human, ,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU115661
MISSION® esiRNA, targeting human CYP2D6,
Especie
human