ATM
ataxia telangiectasia mutated
Sinónimos:
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Especie:
Human ATM (472), Mouse Atm (11920), Rat Atm (300711), Zebrafish atm (403064), cow ATM (526824), Horse ATM (100061765), domestic cat ATM (101089291), dog ATM (479450), chicken ATM (395401), Thale Cress ATM (823975) ...Más
ID UniProtKB:
ID del gen:
- Human(472) Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- Mouse(11920) ataxia telangiectasia mutated homolog (human)
- Rat(300711) ataxia telangiectasia mutated
- Zebrafish(403064) ataxia telangiectasia mutated
- cow(526824) ataxia telangiectasia mutated
- Horse(100061765) ataxia telangiectasia mutated
- domestic cat(101089291) ataxia telangiectasia mutated
- dog(479450) ataxia telangiectasia mutated
- chicken(395401) ataxia telangiectasia mutated
- Thale Cress(823975) serine/threonine-protein kinase ATM
- naked mole-rat(101718948) ataxia telangiectasia mutated
- domestic guinea pig(100717983) ataxia telangiectasia mutated
- sheep(101105847) ataxia telangiectasia mutated
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-p-ATM (Ser1981) Antibody, clone 1E19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
affinity binding assay
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
Anti-Phospho-ATM-S1981 antibody produced in rabbit, ,
Reactividad de especies
human, rat
Aplicación
western blot
Anti-Androgen Receptor (C-term) antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP224, affinity isolated antibody,
Reactividad de especies
human, mouse, pig
Aplicación
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-ATM antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-Phospho-ATM-S1981 antibody produced in rabbit, ,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
western blot